2-Amino-4-methylpyrimidine → 5-Bromo-4-methylpyrimidin-2-amine

HRID 2382609Notes

Reaction equation

HRID 2382609 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[CH:5]=[CH:4][N:3]=1.C1C(=O)N([Br:16])C(=O)C1>C(Cl)(Cl)Cl>[Br:16][C:5]1[C:6]([CH3:8])=[N:7][C:2]([NH2:1])=[N:3][CH:4]=1

Participants

4

Reactant 2

HCID 79392-Amino-4-methylpyrimidineHCID 67184N-bromobutanimide

Product 1

HCID 186161965-Bromo-4-methylpyrimidin-2-amine

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

2-Amino-4-methylpyrimidine (10 g, 91.6 mmol), n-bromosuccinimide (17.9 g, 100.8 mmol) and CHCl3 are mixed together and stirred at room temperature for 1 hour. The solvent is removed in vacuo, water is added and the mixture is stirred at room temperature for 30 minutes. The resulting precipitate is collected by filtration and dried under vacuum oven to afford the title compound.

Workup

  1. customThe solvent is removed in vacuo, water
  2. additionis added
  3. stirringthe mixture is stirred at room temperature for 30 minutes
  4. filtrationThe resulting precipitate is collected by filtration
  5. customdried under vacuum oven

Sources & evidence

ORD record
ord-a4617d07babb465082a00de16df2b31e
Source dataset
uspto-grants-2012_09
Patent number
US08263585B2

Reaction notes

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