Methanol → 3-Methoxy-4-nitrophenol

HRID 2382656Notes

Reaction equation

HRID 2382656 reaction equation
F[C:2]1[CH:3]=[C:4]([OH:11])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[CH3:12][OH:13]>C1COCC1.O(C)[K]>[CH3:12][O:13][C:2]1[CH:3]=[C:4]([OH:11])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9]

Participants

5

Reactant 2

HCID 887MethanolHCID 5209483-Fluoro-4-nitrophenol

Product 1

HCID 129005323-Methoxy-4-nitrophenol

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 178502595HCID 178502595, compoundSolvent

Procedure

To a solution of 3-Fluoro-4-nitro-phenol (15.7 g, 100 mmol) in THF (300 mL), 30% KOMe in Methanol (49 mL, 210 mmol) is added at 0° C. The mixture is heated to gentle reflux for 18 hours.

Workup

  1. temperatureThe mixture is heated
  2. temperatureto gentle reflux for 18 hours

Sources & evidence

ORD record
ord-13b8a80e6edb45529b799664f4d30872
Source dataset
uspto-grants-2012_09
Patent number
US08263590B2

Reaction notes

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