反应详情

A suspension of 5-chloro[1,2,4]triazolo[1,5-a]pyridin-2-amine ((A4), 10.0 g; 59.32 mmol; 1.0 eq.) in cyclohexylamine (60 mL) was heated to reflux for 52 h. Reaction mixture was taken up in MTBE and filtered. The resulting cake was washed with MTBE and filtrate was concentrated to dryness. Residue was purified by flash chromatography (Hept/EtOAc, 1:1) to give the title compound as a beige powder (8.08 g, 59%). HPLC, Rt: 2.46 min. (purity 98.9%). LC/MS, M+(ESI): 231.9.

1. temperaturewas heated
2. temperatureto reflux for 52 h
3. customReaction mixture
4. filtrationfiltered
5. washThe resulting cake was washed with MTBE and filtrate
6. concentrationwas concentrated to dryness
7. customResidue was purified by flash chromatography (Hept/EtOAc, 1:1)