Benzoyl chloride → N-(6-bromo[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzamide

HRID 2382779Notes

Reaction equation

HRID 2382779 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([N:8]=[C:9]([NH2:11])[N:10]=2)[CH:7]=1.[C:12](Cl)(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([N:8]=[C:9]([NH:11][C:12](=[O:19])[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[N:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7412Benzoyl chlorideHCID 252159406-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Product 1

HCID 25212517N-(6-bromo[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzamide

Procedure

The title compound was prepared following procedure described for intermediate B1, but starting from 6-bromo[1,2,4]triazolo[1,5-a]pyridin-2-amine ((AS), 5.0 g; 23.47 mmol; 1.0 eq.) and benzoyl chloride (6.57 g; 46.9 mmol; 2.0 eq.) as a white powder (6.5 g, 87%). HPLC, Rt: 2.49 min. (purity 97.1%). LC/MS, M+(ESI): 317.0, M−(ESI): 316.9.

Sources & evidence

ORD record
ord-b034ae7efb1c4c648f6a5e0a54062eab
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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