Benzoyl chloride → N-(8-bromo[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzamide

HRID 2382783Notes

Reaction equation

HRID 2382783 reaction equation
[Br:1][C:2]1[C:3]2[N:4]([N:8]=[C:9]([NH2:11])[N:10]=2)[CH:5]=[CH:6][CH:7]=1.[C:12](Cl)(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[Br:1][C:2]1[C:3]2[N:4]([N:8]=[C:9]([NH:11][C:12](=[O:19])[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[N:10]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 7412Benzoyl chlorideHCID 468640698-Bromo-(1,2,4)triazolo(1,5-a)pyridin-2-amine

Product 1

HCID 25212767N-(8-bromo[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzamide

Procedure

The title compound was prepared following procedure described for intermediate B1, but starting from 8-bromo[1,2,4]triazolo[1,5-a]pyridin-2-amine ((A15), 4.40 g; 20.7 mmol; 1.0 eq.) and benzoyl chloride (5.81 g; 41.3 mmol; 2.0 eq.) as a white solid (4.9 g, 74%). HPLC, Rt: 2.45 min. (purity 90.1%). LC/MS, M+(ESI): 318.9, M−(ESI): 316.9.

Sources & evidence

ORD record
ord-a73b2d0f8739407f9d5a0d9ba7e542c0
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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