3-Methoxypropylamine → HCID 25213751, compound

HRID 2382827Notes

Reaction equation

HRID 2382827 reaction equation
Cl[C:2]1[N:7]2[N:8]=[C:9]([NH:11][C:12](=[O:19])[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[N:10]=[C:6]2[CH:5]=[CH:4][CH:3]=1.[CH3:20][O:21][CH2:22][CH2:23][CH2:24][NH2:25]>C1COCC1>[CH3:20][O:21][CH2:22][CH2:23][CH2:24][NH:25][C:2]1[N:7]2[N:8]=[C:9]([NH:11][C:12](=[O:19])[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[N:10]=[C:6]2[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 16723-MethoxypropylamineHCID 25212515HCID 25212515, compound

Product 1

HCID 25213751HCID 25213751, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared following procedure described for example 30 but starting from N-(5-chloro[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzamide ((B3), 50 mg; 0.18 mmol; 1.0 eq.) and 3-methoxypropylamine (195 μl; 1.91 mmol; 10.0 eq.) in THF (3.0 mL), 90° C., 12 h, as white needles (35 mg; 56%). HPLC, Rt: 1.95 min. (purity 99.3%). LC/MS, M+(ESI): 326.2.

Sources & evidence

ORD record
ord-f8f403f73227424ba01430b4be82bc74
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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