4-Butylbenzoic acid → 4-butyl-N-[5-(3-furyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]benzamide

HRID 2382837Notes

Reaction equation

HRID 2382837 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:11]3[N:12]=[C:13]([NH2:15])[N:14]=[C:10]3[CH:9]=[CH:8][CH:7]=2)=[CH:2]1.[CH2:16]([C:20]1[CH:28]=[CH:27][C:23]([C:24](O)=[O:25])=[CH:22][CH:21]=1)[CH2:17][CH2:18][CH3:19]>>[CH2:16]([C:20]1[CH:21]=[CH:22][C:23]([C:24]([NH:15][C:13]2[N:14]=[C:10]3[CH:9]=[CH:8][CH:7]=[C:6]([C:3]4[CH:4]=[CH:5][O:1][CH:2]=4)[N:11]3[N:12]=2)=[O:25])=[CH:27][CH:28]=1)[CH2:17][CH2:18][CH3:19]

Participants

3

Reactant 2

HCID 886314-Butylbenzoic acidHCID 252159385-(Furan-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Product 1

HCID 252139774-butyl-N-[5-(3-furyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]benzamide

Procedure

The title compound was prepared following procedure and work up described for example 2, but starting from 5-(3-furyl)[1,2,4]triazolo[1,5-a]pyridin-2-amine ((A2), 75 mg; 0.37 mmol; 1.0 eq.) and 4-butylbenzoic acid (80 mg; 0.45 mmol; 1.2 eq.) as a yellow foam (20 mg, 15%). HPLC, Rt: 4.45 min. (purity 82.6%). LC/MS, M+(ESI): 361.1, M−(ESI): 359.1.

Sources & evidence

ORD record
ord-89aa92c447cf425aaa9a9cf734ea9a19
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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