3-Amino-1,2-propanediol → HCID 25214205, compound

HRID 2382839Notes

Reaction equation

HRID 2382839 reaction equation
Cl[C:2]1[N:7]2[N:8]=[C:9]([NH:11][C:12](=[O:19])[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[N:10]=[C:6]2[CH:5]=[CH:4][CH:3]=1.[NH2:20][CH2:21][CH:22]([OH:25])[CH2:23][OH:24]>>[OH:25][CH:22]([CH2:23][OH:24])[CH2:21][NH:20][C:2]1[N:7]2[N:8]=[C:9]([NH:11][C:12](=[O:19])[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[N:10]=[C:6]2[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 735613-Amino-1,2-propanediolHCID 25212515HCID 25212515, compound

Product 1

HCID 25214205HCID 25214205, compound

Procedure

The title compound was prepared following procedure described for example 30 but starting from N-(5-chloro[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzamide ((B3), 50 mg; 0.18 mmol; 1.0 eq.) and 3-amino-1,2-propanediol (1.0 mL) as a white powder (6 mg, 7%). HPLC, Rt: 1.65 min. (purity 99.5%). LC/MS, M+(ESI): 328.1, M−(ESI): 326.1.

Sources & evidence

ORD record
ord-15d4467794224227939ef3656af24cbe
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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