N-Methylcyclohexylamine → HCID 25214210, compound

HRID 2382849Notes

Reaction equation

HRID 2382849 reaction equation
Cl[C:2]1[N:7]2[N:8]=[C:9]([NH:11][C:12](=[O:19])[C:13]3[CH:18]=[CH:17][CH:16]=[N:15][CH:14]=3)[N:10]=[C:6]2[CH:5]=[CH:4][CH:3]=1.[CH3:20][NH:21][CH:22]1[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1>>[CH:22]1([N:21]([CH3:20])[C:2]2[N:7]3[N:8]=[C:9]([NH:11][C:12](=[O:19])[C:13]4[CH:18]=[CH:17][CH:16]=[N:15][CH:14]=4)[N:10]=[C:6]3[CH:5]=[CH:4][CH:3]=2)[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1

Participants

3

Reactant 2

HCID 7514N-MethylcyclohexylamineHCID 25212516N-(5-chloro[1,2,4]triazolo[1,5-a]pyridin-2-yl)nicotinamide

Product 1

HCID 25214210HCID 25214210, compound

Procedure

The title compound was prepared following procedure described for example 30 but starting from N-(5-chloro[1,2,4]triazolo[1,5-a]pyridin-2-yl)nicotinamide ((B4), 55 mg; 0.20 mmol; 1.0 eq.) and N-methylcyclohexylamine (1.0 mL) as an off white solid (30 mg, 43%). HPLC, Rt: 2.67 min. (purity 97.8%). LC/MS, M+(ESI): 351.4, M−(ESI): 349.4.

Sources & evidence

ORD record
ord-159ca27e60fc4dda9f9c5193baaec60e
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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