3-Pyridinecarbonyl chloride, hydrochloride (1:1) → HCID 59437452, compound

HRID 2382871Notes

Reaction equation

HRID 2382871 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([N:15]=[C:16]([NH2:18])[N:17]=2)[C:7]=1[NH:8][CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1.Cl.[C:20](Cl)(=[O:27])[C:21]1[CH:26]=[CH:25][CH:24]=[N:23][CH:22]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([N:15]=[C:16]([NH:18][C:20](=[O:27])[C:21]3[CH:26]=[CH:25][CH:24]=[N:23][CH:22]=3)[N:17]=2)[C:7]=1[NH:8][CH:9]1[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)HCID 25216191HCID 25216191, compound

Product 1

HCID 59437452HCID 59437452, compound

Procedure

The title compound was prepared following procedure described for intermediate B1, but starting from 6-bromo-N5-cyclohexyl[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine ((A14), 616 mg; 1.99 mmol; 1.0 eq.) and nicotinoyl chloride hydrochloride (424 mg; 2.38 mmol; 1.2 eq.) as a beige powder (99 mg, 12%). HPLC, Rt: 3.41 min. (purity 94.6%). LC/MS, M+(ESI): 416.9.

Sources & evidence

ORD record
ord-ba4df26f745a40b6acd8b5a264d5d30a
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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