Methylamine → HCID 59437481, compound

HRID 2382876Notes

Reaction equation

HRID 2382876 reaction equation
Cl[C:2]1[N:7]2[N:8]=[C:9]([NH:11][C:12](=[O:19])[C:13]3[CH:18]=[CH:17][CH:16]=[N:15][CH:14]=3)[N:10]=[C:6]2[CH:5]=[C:4]([C:20]([F:23])([F:22])[F:21])[CH:3]=1.[CH3:24][NH2:25]>CO>[CH3:24][NH:25][C:2]1[N:7]2[N:8]=[C:9]([NH:11][C:12](=[O:19])[C:13]3[CH:18]=[CH:17][CH:16]=[N:15][CH:14]=3)[N:10]=[C:6]2[CH:5]=[C:4]([C:20]([F:23])([F:22])[F:21])[CH:3]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 25212520HCID 25212520, compound

Product 1

HCID 59437481HCID 59437481, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound was prepared following procedure and work up described for example 85 but starting from N-[5-chloro-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]nicotinamide ((B7), 50 mg; 0.15 mmol; 1.0 eq.) and methylamine (1.46 mL of a 2M solution in MeOH; 0.73 mmol; 5.0 eq.) as a white solid (15 mg, 30%). HPLC, Rt: 2.47 min. (purity 96.6%). LC/MS, M+(ESI): 337.0, M−(ESI): 335.0.

Sources & evidence

ORD record
ord-92b53948a18046748db3cba723369bd5
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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