N5-cyclohexyl[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine → HCID 59437504, compound

HRID 2382880Notes

Reaction equation

HRID 2382880 reaction equation
[CH:1]1([NH:7][C:8]2[N:13]3[N:14]=[C:15]([NH2:17])[N:16]=[C:12]3[CH:11]=[CH:10][CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[N:18]1([CH2:23][CH2:24][C:25]2[CH:33]=[CH:32][C:28]([C:29](Cl)=[O:30])=[CH:27][N:26]=2)[CH2:22][CH2:21][CH2:20][CH2:19]1>>[CH:1]1([NH:7][C:8]2[N:13]3[N:14]=[C:15]([NH:17][C:29](=[O:30])[C:28]4[CH:32]=[CH:33][C:25]([CH2:24][CH2:23][N:18]5[CH2:22][CH2:21][CH2:20][CH2:19]5)=[N:26][CH:27]=4)[N:16]=[C:12]3[CH:11]=[CH:10][CH:9]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 25216186N5-cyclohexyl[1,2,4]triazolo[1,5-a]pyridine-2,5-diamineHCID 86643868HCID 86643868, compound

Product 1

HCID 59437504HCID 59437504, compound

Procedure

The title compound was prepared following procedure described for intermediate B1 but starting from N5-cyclohexyl[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine ((A9), 116 mg; 0.5 mmol; 1.0 eq.) and 6-(2-pyrrolidin-1-ylethyl)nicotinoyl chloride (239 mg, 1.0 mmol; 2.0 eq.) as a white powder (130 mg, 60%). HPLC, Rt: 2.67 min. (purity 99.9%). LC/MS, M+(ESI): 434.1, M−(ESI): 432.1.

Sources & evidence

ORD record
ord-6b6641101e604bd3a17a31e40750de89
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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