Potassium Hydroxide → HCID 23665912, compound

HRID 2382881Notes

Reaction equation

HRID 2382881 reaction equation
[OH-].[K+:2].[OH:3][CH2:4][C:5]1[N:10]=[CH:9][C:8]([C:11]([O:13]CC)=[O:12])=[CH:7][CH:6]=1>C1COCC1>[OH:3][CH2:4][C:5]1[N:10]=[CH:9][C:8]([C:11]([O-:13])=[O:12])=[CH:7][CH:6]=1.[K+:2]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 15045504Ethyl 6-(hydroxymethyl)pyridine-3-carboxylate

Product 1

HCID 23665912HCID 23665912, compoundYield 92.3%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

An aqueous solution of potassium hydroxide (40.4 mmol, 8 mL, 5 N, 2.0 eq.) was added to a solution of ethyl 6-(hydroxymethyl)pyridine-3-carboxylate (3.7 g; 20.4 mmol; 1.0 eq.) (J. Med. Chem. 2004, 47, 5230-5234) in THF (80 mL). The resulting reaction mixture was stirred at rt for 3 h. The precipitate was collected by filtration and dried on under vacuum to give the title compound as a white powder (3.6 g, 92%).

Workup

  1. customThe resulting reaction mixture
  2. filtrationThe precipitate was collected by filtration
  3. customdried on under vacuum

Sources & evidence

ORD record
ord-ac29f3766c204f68b091441c9bb6c134
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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