Hydrogen Peroxide → HCID 58138771, compound

HRID 2382946Notes

Reaction equation

HRID 2382946 reaction equation
[Cl:1][C:2]1[CH:27]=[C:26]([C:28]#[N:29])[CH:25]=[CH:24][C:3]=1[CH2:4][NH:5][C:6]([C:8]1[C:9]2[CH:10]=[N:11][N:12]([C:17]3[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=3)[C:13]=2[CH:14]=[CH:15][CH:16]=1)=[O:7].[OH-:30].[K+].OO.O>C(O)C.O>[C:28]([C:26]1[CH:25]=[CH:24][C:3]([CH2:4][NH:5][C:6]([C:8]2[C:9]3[CH:10]=[N:11][N:12]([C:17]4[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=4)[C:13]=3[CH:14]=[CH:15][CH:16]=2)=[O:7])=[C:2]([Cl:1])[CH:27]=1)(=[O:30])[NH2:29]

Participants

6

Reactant 4

HCID 784Hydrogen PeroxideHCID 962WaterHCID 14797Potassium HydroxideHCID 44469658HCID 44469658, compound

Product 1

HCID 58138771HCID 58138771, compound

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Procedure

To a suspension of 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid 2-chloro-4-cyano-benzylamide in a 1:1 mixture of EtOH—H2O (2.0 mL) was added KOH (0.018 g, 0.32 mmol) and a 30% solution of H2O2 in H2O (0.13 mL, 1.1 mmol). The suspension was sealed and heated briefly to dissolve the mixture. The resultant solution was stirred at room temperature for 16 hours, during which time a solid precipitated. The mixture was diluted with H2O (10 mL) and the solid was collected by filtration and dried to afford the title compound as a white powder.

Workup

  1. customThe suspension was sealed
  2. temperatureheated briefly
  3. dissolutionto dissolve the mixture
  4. customprecipitated
  5. additionThe mixture was diluted with H2O (10 mL)
  6. filtrationthe solid was collected by filtration
  7. customdried

Sources & evidence

ORD record
ord-209f98556e2641b8ac49debf7f5abb59
Source dataset
uspto-grants-2012_09
Patent number
US08263597B2

Reaction notes

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