Succinimide → 1-{3-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]prop-2-en-1-yl}pyrrolidine-2,5-dione

HRID 238298Notes

Reaction equation

HRID 238298 reaction equation
Cl[CH2:2][CH:3]=[CH:4][C:5]1[S:6][CH:7]=[C:8]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)[N:9]=1.[NH:17]1[C:21](=[O:22])[CH2:20][CH2:19][C:18]1=[O:23]>>[F:16][C:13]1[CH:14]=[CH:15][C:10]([C:8]2[N:9]=[C:5]([CH:4]=[CH:3][CH2:2][N:17]3[C:21](=[O:22])[CH2:20][CH2:19][C:18]3=[O:23])[S:6][CH:7]=2)=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 11439SuccinimideHCID 688217062-(3-Chloroprop-1-en-1-yl)-4-(4-fluorophenyl)-1,3-thiazole

Product 1

HCID 688262441-{3-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]prop-2-en-1-yl}pyrrolidine-2,5-dione

Procedure

The compound was prepared analogously to example 3e) from 100 mg (0.39 mmol) of 2-(3-chloropropenyl)-4-(4-fluorophenyl)thiazole and 46.8 mg (0.47 mmol) of pyrrolidine-2,5-dione. Yield: 24 mg (17%).

Sources & evidence

ORD record
ord-7b7c7ac22a5f4f13ad272c3f3ecd7a5f
Source dataset
uspto-grants-2014_02
Patent number
US08642620B2

Reaction notes

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