反应详情

温度

-70 °C

520 mg (2 mmol) of 3-(6-(4-fluorophenyl)pyridin-3-yl)acrylic acid methyl ester were dissolved in 40 ml of dichloromethane and cooled to −70° C. Under argon, 4.65 ml of a 1M solution of diisobutylaluminum hydride in hexane were slowly added. The mixture was stirred at −70° C. for 3 h, quenched with a solution of sodium sulfate, and warmed to room temperature. After filtration over Celite, the organic phase was separated and evaporated. Yield: 430 mg (93%)

1. customquenched with a solution of sodium sulfate
2. temperaturewarmed to room temperature
3. filtrationAfter filtration over Celite
4. customthe organic phase was separated
5. customevaporated