HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 238300Generated: October 30, 2026
Diisobutylaluminumhydride → 3-(6-(4-Fluorophenyl)pyridin-3-yl)prop-2-en-1-ol
https://huagongshe.com/reaction/238300
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisobutylaluminumhydride | HCID 21225700 | — |
| Reactant | Methyl 3-[6-(4-fluorophenyl)pyridin-3-yl]prop-2-enoate | HCID 68821839 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | 3-(6-(4-Fluorophenyl)pyridin-3-yl)prop-2-en-1-ol | HCID 68821919 | — |
Reaction Steps
520 mg (2 mmol) of 3-(6-(4-fluorophenyl)pyridin-3-yl)acrylic acid methyl ester were dissolved in 40 ml of dichloromethane and cooled to −70° C. Under argon, 4.65 ml of a 1M solution of diisobutylaluminum hydride in hexane were slowly added. The mixture was stirred at −70° C. for 3 h, quenched with a solution of sodium sulfate, and warmed to room temperature. After filtration over Celite, the organic phase was separated and evaporated. Yield: 430 mg (93%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08642620B2 |
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| Source dataset | uspto-grants-2014_02 |
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| ORD ID | ord-7edcdd7411e44802927b46eae144e2d6 |
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| Source note | uspto-grants-2014_02 |
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