反应详情

1-cyclohexyl-1,2,3,4-tetrahydroisoquinoline hydrochloride (800 mg) was dissolved in methylene chloride (12 mL), to which triethylamine (1.1 mL) and acryloyl chloride (0.28 mL) were then added under ice-cooling, followed by stirring under ice-cooling for 30 minutes and then stirring at room temperature for 14 hours. Water was added to the reaction liquid which was then extracted with chloroform. The extract was washed with saturated brine and dried over magnesium sulfate. The solvent was evaporated to obtain 2 acryloyl-1-cyclohexyl-1,2,3,4-tetrahydroisoquinoline (856 mg).

1. additionwere then added under ice-
2. temperaturecooling
3. temperaturecooling for 30 minutes
4. stirringstirring at room temperature for 14 hours
5. extractionwas then extracted with chloroform
6. washThe extract was washed with saturated brine
7. dry with materialdried over magnesium sulfate
8. customThe solvent was evaporated