Sodium borohydride → HCID 67538376, compound

HRID 2383053Notes

Reaction equation

HRID 2383053 reaction equation
[CH:1]1([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:17]([NH:19][CH2:20][CH:21]([CH3:23])[CH3:22])=[O:18])[CH:15]=3)[CH2:10][CH2:9][N:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[BH4-].[Na+]>CO>[CH:1]1([CH:7]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:17]([NH:19][CH2:20][CH:21]([CH3:23])[CH3:22])=[O:18])[CH:15]=3)[CH2:10][CH2:9][NH:8]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 67535969HCID 67535969, compound

Product 1

HCID 67538376HCID 67538376, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-cyclohexyl-N-isobutyl-3,4-dihydroisoquinoline-7-carboxamide (689 mg) was dissolved in MeOH (12 mL). Sodium borohydride (100 mg) was added to the reaction mixture, followed by stirring at room temperature for 5 hours. The solvent was evaporated. To the resulting residue were added water and chloroform. The residue was extracted with chloroform and dried over magnesium sulfate. Then, the solvent was evaporated under reduced pressure to obtain 1-cyclohexyl-N-isobutyl-1,2,3,4-tetrahydroisoquinoline-7-carboxamide.

Workup

  1. customThe solvent was evaporated
  2. additionTo the resulting residue were added water and chloroform
  3. extractionThe residue was extracted with chloroform
  4. dry with materialdried over magnesium sulfate
  5. customThen, the solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-80c26d920e0f4cd2bf3d275f284e6bed
Source dataset
uspto-grants-2012_09
Patent number
US08263607B2

Reaction notes

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