反应详情

A solution of hydrochloric acid (5 mL of 1.5 M in ethanol) was added to a mixture of tert-butyl{4-[4-amino-7-benzyloxy-1-(2-phenoxyethyl)-1H-imidazo[4,5-c]quinolin-2-yl]butyl}carbamate (823 mg, 1.41 mmol) and ethanol. The reaction was heated at reflux for 30 minutes and became homogeneous. The solvent was removed under reduced pressure. The residue was recrystallized from methanol, isolated by filtration, washed with diethyl ether, and dried under reduced pressure to provide 534 mg of 2-(4-aminobutyl)-7-benzyloxy-1-(2-phenoxyethyl)-1H-imidazo[4,5-c]quinolin-4-amine as yellow crystals.

1. temperatureThe reaction was heated
2. temperatureat reflux for 30 minutes
3. customThe solvent was removed under reduced pressure
4. customThe residue was recrystallized from methanol
5. customisolated by filtration
6. washwashed with diethyl ether
7. customdried under reduced pressure