反应详情

温度

100 °C

Methylamine (available as a 40% solution in water, 21 mL, 0.25 mol) was added to a suspension of 6-benzyloxy-4-chloro-3-nitroquinoline (13.74 g, 43.65 mmol) in distilled water (300 mL), and the reaction was stirred at 100° C. for 1.5 hours. The reaction was allowed to cool to ambient temperature and stirred for three hours. A precipitate formed, which was isolated by filtration, washed with distilled water (3×), and recrystallized from 2-propanol (44.2 mL/g). The crystals were isolated by filtration and washed with cold hexanes (2×100 mL) to provide 11.36 g of N-(6-benzyloxy-3-nitroquinolin-4-yl)-N-methylamine as orange crystals.

1. temperatureto cool to ambient temperature
2. stirringstirred for three hours
3. customA precipitate formed
4. customwhich was isolated by filtration
5. washwashed with distilled water (3×)
6. customrecrystallized from 2-propanol (44.2 mL/g)
7. customThe crystals were isolated by filtration
8. washwashed with cold hexanes (2×100 mL)