反应详情

Trifluoroacetic acid (1.0 ml, 13.0 mmol) was added dropwise at 25° C. under nitrogen to a solution of (6-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2-{[(1,1-dimethylethyl)oxy]carbonyl}-5-methyl-1,2,3,4-tetrahydro-1-isoquinolinyl)acetic acid (Preparation 22; 75 mg, 0.138 mmol) in dichloromethane (3 ml) and the mixture was stirred at room temperature for 1 h. The solvent was removed in vacuo and the residue co-evaporated with toluene, dried for 20 min under vacuum then triturated with diethyl ether to give a pale brown solid (45 mg). Purification by MDAP gave the title compound (8.2 mg) as a white solid.

1. customThe solvent was removed in vacuo
2. dry with materialthe residue co-evaporated with toluene, dried for 20 min under vacuum
3. customthen triturated with diethyl ether