反应详情

Trifluoroacetic acid (1.0 ml) was added to a stirred solution of 4-(6-(5-{5-chloro-6-[(1-methylethyl)oxy]-3-pyridinyl}-1,2,4-oxadiazol-3-yl)-2-{[(1,1-dimethylethyl)oxy]carbonyl}-5-methyl-1,2,3,4-tetrahydro-1-isoquinolinyl)butanoic acid (Preparation 34; 50 mg, 0.09 mmol) in dry dichloromethane (3 ml). The reaction mixture was stirred at room temperature for 2 hours. The solvents were evaporated and the residue co-evaporated with toluene. Trituration of the residue with diethyl ether gave a gummy solid, which was purified by MDAP to give the title compound (26 mg) as a colourless solid.

1. customThe solvents were evaporated
2. customTrituration of the residue with diethyl ether gave a gummy solid, which
3. customwas purified by MDAP