HCID 67309189, compound → HCID 15539217, compound

HRID 2383335Notes

Reaction equation

HRID 2383335 reaction equation
Br[C:2]1[C:3]([CH3:16])=[CH:4][CH:5]=[C:6]2[C:11]=1[CH:10]=[C:9]([C:12]([OH:14])=[O:13])[CH:8]=[C:7]2[OH:15]>C(O)C.[C].[Pd]>[OH:15][C:7]1[C:6]2[C:11](=[CH:2][C:3]([CH3:16])=[CH:4][CH:5]=2)[CH:10]=[C:9]([C:12]([OH:14])=[O:13])[CH:8]=1

Participants

4

Reactant 1

HCID 67309189HCID 67309189, compound

Product 1

HCID 15539217HCID 15539217, compoundYield 98.9%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

To a solution of 8-bromo-4-hydroxy-7-methylnaphthalene-2-carboxylic acid (0.45 g) in ethanol (8 mL) was added palladium-carbon (180 mg) in 3 parts, and the mixture was stirred at room temperature for 2 days under a hydrogen atmosphere. The insoluble material was removed by filtering through a Celite pad, and the filtrate was concentrated to give the title compound (0.32 g).

Workup

  1. customThe insoluble material was removed
  2. filtrationby filtering through a Celite pad
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-8a76776f05be4de3989f4d05de0a35ab
Source dataset
uspto-grants-2012_09
Patent number
US08263622B2

Reaction notes

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