反应详情

温度

90 °C

Cyclohexyl-phenyl-(1-piperidin-4-ylmethyl-1H-[1,2,4]triazol-3-yl)-methanol (Preparation 4, 0.40 g, 1.13 mmol) and 2-{2-[4-(2-Bromo-ethyl)-phenyl]-ethyl}-isoindole-1,3-dione (Preparation 11, 0.404 g, 1.13 mmol) and diisopropylethylamine (0.59 ml, 3.38 mmol) were dissolved in methyl ethyl ketone (8 mL). After stirring at 90° C. for 24 hours the reaction was allowed to cool slowly to room temperature. Crystallisation occured and the resulting solid was collected by filtration and dried in vacuo to yield the title compound as a cream coloured solid, in 74% yield, 0.532 g.

1. temperatureto cool slowly to room temperature
2. customCrystallisation
3. filtrationthe resulting solid was collected by filtration
4. customdried in vacuo