tert-Butyl 4-(bromomethyl)piperidine-1-carboxylate → Tert-butyl-4-({3-[cyclohexyl(hydroxy)phenylmethyl]-1H-1,2,4-triazol-1-yl}methyl)piperidine-1-carboxylate

HRID 2383379Notes

Reaction equation

HRID 2383379 reaction equation
[CH:1]1([C:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)([C:9]2[N:13]=[CH:12][NH:11][N:10]=2)[OH:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:20]([O:24][C:25]([N:27]1[CH2:32][CH2:31][CH:30]([CH2:33]Br)[CH2:29][CH2:28]1)=[O:26])([CH3:23])([CH3:22])[CH3:21]>>[C:20]([O:24][C:25]([N:27]1[CH2:32][CH2:31][CH:30]([CH2:33][N:11]2[CH:12]=[N:13][C:9]([C:7]([CH:1]3[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]3)([OH:8])[C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[N:10]2)[CH2:29][CH2:28]1)=[O:26])([CH3:23])([CH3:21])[CH3:22]

Participants

3

Reactant 2

HCID 15512811tert-Butyl 4-(bromomethyl)piperidine-1-carboxylateHCID 178519503HCID 178519503, compound

Product 1

HCID 59145964Tert-butyl-4-({3-[cyclohexyl(hydroxy)phenylmethyl]-1H-1,2,4-triazol-1-yl}methyl)piperidine-1-carboxylateYield 47%

Procedure

The title compound was prepared from cyclohexyl(phenyl)1H-1,2,4-triazol-3-ylmethanol (Preparation 18, 500 mg, 1.94 mmol) and tert-butyl4-(bromomethyl)piperidine-1-carboxylate (649 mg, 2.33 mmol) using the same method as described in preparation 3, to give a clear oil, in 47% yield, 415 mg.

Workup

  1. customas described in preparation 3
  2. customto give a clear oil

Sources & evidence

ORD record
ord-0da6ad7484894240a1682c3710187ff9
Source dataset
uspto-grants-2012_09
Patent number
US08263623B2

Reaction notes

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