tert-Butyl 4-(bromomethyl)piperidine-1-carboxylate → Tert-butyl-4-({3-[cyclohexyl(hydroxy)phenylmethyl]-1H-1,2,4-triazol-1-yl}methyl)piperidine-1-carboxylate

Participants

Reaction Steps

The title compound was prepared from cyclohexyl(phenyl)1H-1,2,4-triazol-3-ylmethanol (Preparation 18, 500 mg, 1.94 mmol) and tert-butyl4-(bromomethyl)piperidine-1-carboxylate (649 mg, 2.33 mmol) using the same method as described in preparation 3, to give a clear oil, in 47% yield, 415 mg.

Provenance & Evidence