反应详情

To a stirred solution of 2-methyl-7-oxo-4,5,6,7-tetrahydrobenzo[d]thiazole-6-carbaldehyde (5 g, 25.6 mmol) in toluene (50 mL) and diethylether (25 mL) was added dimethylamine (15 mL, 35 mmol) as a solution in THF. The reaction was stirred for at room temperature for 40 hours. The reaction was then concentrated under reduced pressure to give a brown residue, which was triturated with hexane to give the desired product (5.0 g, 87%) as a solid. 1H NMR (DMSO-d6, 400 MHz): δ 7.35 (s, 1H), 3.10 (s, 6H), 2.98 (t, J=6.2 Hz, 2H), 2.82 (t, J=6.2 Hz, 2H), 2.65 (s, 3H); LCMS [M+H]: 223.

1. concentrationThe reaction was then concentrated under reduced pressure
2. customto give a brown residue, which
3. customwas triturated with hexane