m-Aminoacetanilide → N-(3-{[3-(acetylamino)phenyl]carbamoyl}phenyl)-3,6,8,9-tetrahydro-7H-pyrazolo[3,4-c][2,7]naphthyridine-7-carboxamide

HRID 2383449Notes

Reaction equation

HRID 2383449 reaction equation
COC1C=CC(C[N:8]2[C:12]3[N:13]=[CH:14][C:15]4[CH2:16][N:17]([C:21]([NH:23][C:24]5[CH:25]=[C:26]([CH:30]=[CH:31][CH:32]=5)[C:27](O)=[O:28])=[O:22])[CH2:18][CH2:19][C:20]=4[C:11]=3[CH:10]=[N:9]2)=CC=1.[NH2:35][C:36]1[CH:37]=[C:38]([NH:42][C:43](=[O:45])[CH3:44])[CH:39]=[CH:40][CH:41]=1>>[C:43]([NH:42][C:38]1[CH:37]=[C:36]([NH:35][C:27]([C:26]2[CH:25]=[C:24]([NH:23][C:21]([N:17]3[CH2:16][C:15]4[CH:14]=[N:13][C:12]5[NH:8][N:9]=[CH:10][C:11]=5[C:20]=4[CH2:19][CH2:18]3)=[O:22])[CH:32]=[CH:31][CH:30]=2)=[O:28])[CH:41]=[CH:40][CH:39]=1)(=[O:45])[CH3:44]

Participants

3

Reactant 2

HCID 7604m-AminoacetanilideHCID 594904523-(3-(4-methoxybenzyl)-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c][2,7]naphthyridine-7-carboxamido)benzoic acid

Product 1

HCID 59490601N-(3-{[3-(acetylamino)phenyl]carbamoyl}phenyl)-3,6,8,9-tetrahydro-7H-pyrazolo[3,4-c][2,7]naphthyridine-7-carboxamide

Procedure

The compound N-(3-{[3-(acetylamino)phenyl]carbamoyl}phenyl)-3,6,8,9-tetrahydro-7H-pyrazolo[3,4-c][2,7]naphthyridine-7-carboxamide was prepared using 3-(3-(4-methoxybenzyl)-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c][2,7]naphthyridine-7-carboxamido)benzoic acid and N-(3-aminophenyl)acetamide as described in general procedure J. The compound was obtained as a solid. LCMS [M+H]: 470.

Workup

  1. customThe compound was obtained as a solid

Sources & evidence

ORD record
ord-d4b9c08cb30f46dfb93d9a2bb2086b96
Source dataset
uspto-grants-2012_09
Patent number
US08263610B2

Reaction notes

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