反应详情

To a solution of 3-(4-methoxy-benzyl)-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c][2,7]naphthyridine (0.131 g, 0.44 mmol) in dichloromethane (5 mL) was added phenyl isothiocyanate (58 μL, 0.48 mmol). The reaction mixture was shaken at room temperature for 2 hours. The solvent was then removed under reduced pressure to give 3-(4-methoxybenzyl)-N-phenyl-8,9-dihydro-3H-pyrazolo[3,4-c][2,7]naphthyridine-7(6H)-carbothioamide as a solid residue (LCMS [M+H]: 430), which was used for next step without further purification.

1. customThe solvent was then removed under reduced pressure