5-[4-[6-(4-aminophenoxy)-1-methyl-1H-benzimidazol-2-ylmethoxy]benzyl]thiazolidine-2,4-dione dihydrochloride → HCID 10186152, compound

HRID 2383494Notes

Reaction equation

HRID 2383494 reaction equation
Cl.Cl.[NH2:3][C:4]1[CH:36]=[CH:35][C:7]([O:8][C:9]2[CH:10]=[CH:11][C:12]3[N:16]=[C:15]([CH2:17][O:18][C:19]4[CH:32]=[CH:31][C:22]([CH2:23][CH:24]5[S:28][C:27](=[O:29])[NH:26][C:25]5=[O:30])=[CH:21][CH:20]=4)[N:14]([CH3:33])[C:13]=3[CH:34]=2)=[CH:6][CH:5]=1.Cl.Cl.[CH:39](NC1C=C(C=CC=1)OC1C=CC2N=C(COC3C=CC(CC4SC(=O)NC4=O)=CC=3)N(C)C=2C=1)([CH3:41])[CH3:40]>CC(C)=O>[CH:39]([NH:3][C:4]1[CH:36]=[CH:35][C:7]([O:8][C:9]2[CH:10]=[CH:11][C:12]3[N:16]=[C:15]([CH2:17][O:18][C:19]4[CH:32]=[CH:31][C:22]([CH2:23][CH:24]5[S:28][C:27](=[O:29])[NH:26][C:25]5=[O:30])=[CH:21][CH:20]=4)[N:14]([CH3:33])[C:13]=3[CH:34]=2)=[CH:6][CH:5]=1)([CH3:41])[CH3:40]

Participants

4

Reactant 2

HCID 865877685-[4-[6-(4-aminophenoxy)-1-methyl-1H-benzimidazol-2-ylmethoxy]benzyl]thiazolidine-2,4-dione dihydrochlorideHCID 87673801HCID 87673801, compound

Product 1

HCID 10186152HCID 10186152, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

5-(4-(6-(4-Amino-phenoxy)-1-methyl-1H-benzimidazol-2-ylmethoxy)-benzyl)-thiazolidine-2,4-dione.dihydrochloride (Japanese Patent Application (Kokai) No. Hei 11-193276) was used in place of 5-(4-(6-(3-isopropylamino-phenoxy)-1-methyl-1H-benzimidazol-2-ylmethoxy)-benzyl)-thiazolidine-2,4-dione.dihydrochloride of Production Example 4, and acetone was used in place of acetaldehyde to give the title compound in similar manner to Production Example 4.

Sources & evidence

ORD record
ord-e76a5a09d71b498fb838efa43e86f097
Source dataset
uspto-grants-2012_09
Patent number
US08263631B2

Reaction notes

Loading…