反应详情

Under cooling in an ice bath, N,N′-dimethylethylenediamine (414 mg) and triethylamine (1.10 mL) were added to a chloroform (10 mL) solution of 3-bromobenzenesulfonyl chloride (1.00 g), and the obtained solution was then stirred at a room temperature for 45 minutes. The reaction solution was washed with water, and was then dried over anhydrous sodium sulfate, followed by vacuum concentration. The residue was purified by column chromatography (silica gel 60N, chloroform:methanol=98:2 to 96:4), so as to obtain the title compound (1.14 g) in the form of a colorless solid.

1. temperatureUnder cooling in an ice bath
2. washThe reaction solution was washed with water
3. dry with materialwas then dried over anhydrous sodium sulfate
4. concentrationfollowed by vacuum concentration
5. customThe residue was purified by column chromatography (silica gel 60N, chloroform:methanol=98:2 to 96:4)