反应详情

1-(3-Acetyl-4-fluoro-phenyl)-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one (160 mg, 0.513 mmol) in hydrazine hydrate (5 mL) was taken in a reaction flask and the flask was heated to reflux and maintained for 21 hours. The reaction was monitored by TLC (10% MeOH in CHCl3). The reaction mixture was partitioned between ethylacetate and water. The organic layer was dried over Na2SO4, filtered and the filtrate was concentrated. Purification by column chromatography on silica gel (3% MeOH in CHCl3), followed by preparative HPLC afforded 22 mg of the product (14% yield).

1. temperaturethe flask was heated
2. temperatureto reflux
3. temperaturemaintained for 21 hours
4. customThe reaction mixture was partitioned between ethylacetate and water
5. dry with materialThe organic layer was dried over Na2SO4
6. filtrationfiltered
7. concentrationthe filtrate was concentrated
8. customPurification by column chromatography on silica gel (3% MeOH in CHCl3)