反应详情

60% Sodium hydride (390 mg) was added to a dimethylformamide (9.0 mL) solution of (1-methyl-1H-pyrazol-5-yl)methanol (1.00 g) at a room temperature, and the obtained solution was then stirred for 2 hours. Thereafter, 2,5-difluoropyridine (1.17 g) was added to the reaction solution, and the mixed solution was then stirred for 16 hours. Subsequently, water was added to the reaction solution, and the obtained mixture was then extracted with hexane/ethyl acetate (1/2). The organic layer was concentrated under a reduced pressure. The residue was purified by column chromatography (silica gel cartridge, hexane/ethyl acetate=95:5 to 60:40), so as to obtain the title compound (1.08 g) in the form of a colorless solid.

1. stirringthe mixed solution was then stirred for 16 hours
2. extractionthe obtained mixture was then extracted with hexane/ethyl acetate (1/2)
3. concentrationThe organic layer was concentrated under a reduced pressure
4. customThe residue was purified by column chromatography (silica gel cartridge, hexane/ethyl acetate=95:5 to 60:40)