反应详情

To a solution of the compound obtained in example 13 (170 mg, 0.46 mmol) in 5 ml of dry DMF was added ethyl bromoacetate (84.5 mg, 0.5 mmol) and cesium carbonate (195.6 mg, 0.6 mmol) at room temperature for 1 hr. Once the reaction has completed, the reaction mass was diluted with water and extracted with ethyl acetate. The organic layer was washed with water, followed by brine, and concentrated under vacuum. The crude product was purified by column chromatography to get 175 mg (83.2% yields) of the product. MP-106.2-125.1° C.

1. extractionextracted with ethyl acetate
2. washThe organic layer was washed with water
3. concentrationconcentrated under vacuum
4. customThe crude product was purified by column chromatography
5. customto get
6. custom175 mg (83.2% yields) of the product