2-Fluoro-4-nitrophenol → Phenol, 4-amino-2-fluoro-

HRID 238404Notes

Reaction equation

HRID 238404 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[OH:11]>CO.[Pd]>[NH2:8][C:6]1[CH:5]=[CH:4][C:3]([OH:11])=[C:2]([F:1])[CH:7]=1

Participants

4

Reactant 1

HCID 98252-Fluoro-4-nitrophenol

Product 1

HCID 2735918Phenol, 4-amino-2-fluoro-Yield 86%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Under H2, a mixture of 2-fluoro-4-nitrophenol (10 g, 63.7 mmol) and Pd/C (1 g) in methanol (100 mL) was stirred at room temperature for 5 hours. The mixture was filtered, and concentrated in vacuo to give the compound 2A-1 (7 g, yield 86%).

Workup

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated in vacuo
  3. customto give the compound 2A-1 (7 g, yield 86%)

Sources & evidence

ORD record
ord-38611150c2d34da9bd33717983526c26
Source dataset
uspto-grants-2014_02
Patent number
US08642628B2

Reaction notes

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