Hydrochloric Acid → HCID 53904370, compound

HRID 2384068Notes

Reaction equation

HRID 2384068 reaction equation
C([O:3][C:4](=[O:13])[CH2:5][C:6]1[S:7][C:8]([CH2:11][CH3:12])=[N:9][N:10]=1)C.[OH-].[Na+].Cl>C(O)C>[CH2:11]([C:8]1[S:7][C:6]([CH2:5][C:4]([OH:13])=[O:3])=[N:10][N:9]=1)[CH3:12]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67505705(5-Ethyl-[1,3,4]thiadiazol-2-yl)-acetic acid ethyl ester

Product 1

HCID 53904370HCID 53904370, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Next, to a solution of (5-ethyl-[1,3,4]thiadiazol-2-yl)-acetic acid ethyl ester (230 mg, 1.15 mmol) in ethanol (5 mL) is added aqueous 1M NaOH (2 mL, 2.0 mmol) and the mixture is stirred at room temperature for 18 hours. The mixture is acidified with aqueous 1M HCl and the ethanol is removed under reduced pressure. The remaining aqueous solution is lyophilized to give (5-ethyl-[1,3,4]thiadiazol-2-yl)-acetic acid.

Workup

  1. customthe ethanol is removed under reduced pressure

Sources & evidence

ORD record
ord-4d612c813040417f91833d76880ca0f6
Source dataset
uspto-grants-2012_09
Patent number
US08263629B2

Reaction notes

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