Chloride → HCID 57883879, compound

HRID 2384189Notes

Reaction equation

HRID 2384189 reaction equation
[CH:1]1([N:7]([CH:29]2[CH2:34][CH2:33][NH2+:32][CH2:31][CH2:30]2)[C:8]([NH:10][C:11]2[S:12][C:13]([CH2:16][N:17]3[CH2:22][CH2:21][N:20]([S:23](=[O:28])(=[O:27])[N:24]([CH3:26])[CH3:25])[CH2:19][CH2:18]3)=[CH:14][N:15]=2)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl-].[C:36](Cl)(=[O:40])[CH2:37][CH2:38][CH3:39]>>[CH3:25][N:24]([CH3:26])[S:23]([N:20]1[CH2:21][CH2:22][N:17]([CH2:16][C:13]2[S:12][C:11]([NH:10][C:8]([N:7]([CH:29]3[CH2:30][CH2:31][N:32]([C:36](=[O:40])[CH2:37][CH2:38][CH3:39])[CH2:33][CH2:34]3)[CH:1]3[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]3)=[O:9])=[N:15][CH:14]=2)[CH2:18][CH2:19]1)(=[O:28])=[O:27]

Participants

4

Reactant 3

HCID 312ChlorideHCID 8855Butyryl chlorideHCID 86611197HCID 86611197, compound

Product 1

HCID 57883879HCID 57883879, compound

Procedure

Prepared in 70% (204 mg) yield as described in general procedure (N) from 4-{1-cyclohexyl-3-[5-(4-dimethylsulfamoyl-piperazin-1-ylmethyl)-thiazol-2-yl]-ureido}-piperidinium; chloride (275 mg) and butyryl chloride (64 mg, 0.6 mmol).

Workup

  1. customPrepared in 70% (204 mg)
  2. customyield

Sources & evidence

ORD record
ord-faa26658891c4509aff9eec27abec655
Source dataset
uspto-grants-2012_09
Patent number
US08263634B2

Reaction notes

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