Chloride → HCID 57883726, compound

HRID 2384190Notes

Reaction equation

[CH:1]1([N:7]([CH:28]2[CH2:33][CH2:32][NH2+:31][CH2:30][CH2:29]2)[C:8]([NH:10][C:11]2[S:12][C:13]([CH2:16][N:17]3[CH2:22][CH2:21][N:20]([S:23]([CH2:26][CH3:27])(=[O:25])=[O:24])[CH2:19][CH2:18]3)=[CH:14][N:15]=2)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl-].[CH:35]1([C:40](Cl)=[O:41])[CH2:39][CH2:38][CH2:37][CH2:36]1>>[CH:1]1([N:7]([CH:28]2[CH2:33][CH2:32][N:31]([C:40]([CH:35]3[CH2:39][CH2:38][CH2:37][CH2:36]3)=[O:41])[CH2:30][CH2:29]2)[C:8]([NH:10][C:11]2[S:12][C:13]([CH2:16][N:17]3[CH2:22][CH2:21][N:20]([S:23]([CH2:26][CH3:27])(=[O:25])=[O:24])[CH2:19][CH2:18]3)=[CH:14][N:15]=2)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

Reactant 3

HCID 312Chloride

HCID 78284Cyclopentanecarbonyl chloride

HCID 86611199HCID 86611199, compound

Product 1

HCID 57883726HCID 57883726, compound

Procedure

Prepared in 65% (193 mg) yield as described in general procedure (N) from 4-{1-cyclohexyl-3-[5-(4-ethanesulfonyl-piperazin-1-ylmethyl)-thiazol-2-yl]-ureido}-piperidinium; chloride (268 mg, 0.5 mmol) and cyclopentanecarbonyl chloride (80 mg, 0.6 mmol).

Workup

customPrepared in 65% (193 mg)
customyield

Sources & evidence

ORD record: ord-db76853def8144519d0087b932057e54
Source dataset: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08263634B2

Reaction notes

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