Chloride → HCID 178501020, compound

HRID 2384193Notes

Reaction equation

HRID 2384193 reaction equation
[CH:1]1([N:7]([C@H:18]2[CH2:23][CH2:22][C@H:21]([CH3:24])[CH2:20][CH2:19]2)[C:8]([NH:10][C:11]2[S:12][C:13]([CH:16]=O)=[CH:14][N:15]=2)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:25][O:26][C:27]([CH2:29][CH2:30][S:31]([N:34]1[CH2:39][CH2:38][NH2+:37][CH2:36][CH2:35]1)(=[O:33])=[O:32])=[O:28].[Cl-]>>[CH3:25][O:26][C:27](=[O:28])[CH2:29][CH2:30][S:31]([N:34]1[CH2:35][CH2:36][N:37]([CH2:16][C:13]2[S:12][C:11]([NH:10][C:8]([N:7]([CH:1]3[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]3)[C@H:18]3[CH2:19][CH2:20][C@H:21]([CH3:24])[CH2:22][CH2:23]3)=[O:9])=[N:15][CH:14]=2)[CH2:38][CH2:39]1)(=[O:32])=[O:33]

Participants

4

Reactant 3

HCID 312ChlorideHCID 866112014-(2-Methoxycarbonyl-ethanesulfonyl)-piperazin-1-iumHCID 178461373HCID 178461373, compound

Product 1

HCID 178501020HCID 178501020, compound

Procedure

Prepared in 60% (342 mg) yield as described in general procedure (B) from trans-1-cyclohexyl-3-(5-formyl-thiazol-2-yl)-1-(4-methyl-cyclohexyl)-urea (349 mg, 1.0 mmol) and 4-(2-methoxycarbonyl-ethanesulfonyl)-piperazin-1-ium; chloride (273 mg, 1.0 mmol).

Workup

  1. customPrepared in 60% (342 mg)
  2. customyield

Sources & evidence

ORD record
ord-ef1ea03c4c55403dbfb8abcf981d3697
Source dataset
uspto-grants-2012_09
Patent number
US08263634B2

Reaction notes

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