5-Chlorosalicylic Acid → 2-(5-Chloro-2-hydroxybenzoyl)amino-4,5,6,7-tetrahydrobenzo[b]-thiophene-3-carboxylic acid ethyl ester

HRID 2384330Notes

Reaction equation

HRID 2384330 reaction equation
[Cl:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[CH2:12]([O:14][C:15]([C:17]1[C:18]2[CH2:26][CH2:25][CH2:24][CH2:23][C:19]=2[S:20][C:21]=1[NH2:22])=[O:16])[CH3:13]>>[CH2:12]([O:14][C:15]([C:17]1[C:18]2[CH2:26][CH2:25][CH2:24][CH2:23][C:19]=2[S:20][C:21]=1[NH:22][C:7](=[O:9])[C:6]1[CH:10]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=1[OH:11])=[O:16])[CH3:13]

Participants

3

Reactant 2

HCID 94475-Chlorosalicylic AcidHCID 78262Ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Product 1

HCID 100683112-(5-Chloro-2-hydroxybenzoyl)amino-4,5,6,7-tetrahydrobenzo[b]-thiophene-3-carboxylic acid ethyl esterYield 49.6%

Procedure

Using 5-chlorosalicylic acid and 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ethyl ester as the raw materials, the same operation as the example 16 gave the title compound.

Sources & evidence

ORD record
ord-5bf4280aab9d403c85c5b570049a2b6b
Source dataset
uspto-grants-2012_09
Patent number
US08263657B2

Reaction notes

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