反应详情

5-Acetyl-N-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxybenzamide (50.5 mg, 0.13 mmol) was suspended in ethanol (2 mL). Sodium borohydride (23.6 mg, 0.62 mmol) was added, and the mixture was stirred at room temperature for 12 hours. The reaction mixture was poured into diluted hydrochloric acid and extracted with ethyl acetate. After the organic layer was washed with water and brine, dried over anhydrous sodium sulfate, the residue obtained by evaporation under reduced pressure was washed with isopropyl ether/n-hexane under suspension to give the title compound (39.7 mg, 78.3%) as white powder.

1. extractionextracted with ethyl acetate
2. washAfter the organic layer was washed with water and brine
3. dry with materialdried over anhydrous sodium sulfate
4. customthe residue obtained by evaporation under reduced pressure
5. washwas washed with isopropyl ether/n-hexane under suspension