反应详情

Under argon atmosphere, a mixture of 5-amino-N-[3,5-bis(trifluoromethyl)-phenyl]-2-hydroxybenzamide (364 mg, 1 mmol), pyridine (95 mg, 1.2 mmol) and tetrahydrofuran (10 mL) was cooled on ice. Benzoyl chloride (155 mg, 1.1 mmol) was added, and the mixture was stirred for 1 hour. The reaction mixture was poured into water and extracted with ethyl acetate. After the organic layer was washed with water and brine, dried over anhydrous magnesium sulfate, the residue obtained by evaporation under reduced pressure was purified by chromatography on silica gel (n-hexane:ethyl acetate=4:1) to give the title compound (121 mg, 25.7%) as a white solid.

1. temperaturewas cooled on ice
2. extractionextracted with ethyl acetate
3. washAfter the organic layer was washed with water and brine
4. dry with materialdried over anhydrous magnesium sulfate
5. customthe residue obtained by evaporation under reduced pressure
6. customwas purified by chromatography on silica gel (n-hexane:ethyl acetate=4:1)