1-(2-Chloroethyl)pyrrolidine → 1-[2-(5-Nitro-2-trifluoromethylphenoxy)ethyl]-pyrrolidine

HRID 238448Notes

Reaction equation

HRID 238448 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([C:11]([F:14])([F:13])[F:12])=[C:8]([OH:10])[CH:9]=1)([O-:3])=[O:2].Cl[CH2:16][CH2:17][N:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1.C(C1C=CC([N+]([O-])=O)=CC=1OCCN1CCCCC1)(C)(C)C>>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([C:11]([F:12])([F:13])[F:14])=[C:8]([CH:9]=1)[O:10][CH2:16][CH2:17][N:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1)([O-:3])=[O:2]

Participants

4

Reactant 3

HCID 816691-(2-Chloroethyl)pyrrolidineHCID 219595061-[2-(2-Tert-butyl-5-nitro-phenoxy)-ethyl]-piperidineHCID 219595865-Nitro-2-(trifluoromethyl)phenol

Product 1

HCID 219594941-[2-(5-Nitro-2-trifluoromethylphenoxy)ethyl]-pyrrolidine

Procedure

1-[2-(5-Nitro-2-trifluoromethylphenoxy)ethyl]-pyrrolidine was prepared from 5-nitro-2-trifluoromethyl-phenol and 1-(2-chloroethyl)pyrrolidine by a procedure similar to that described for 1-[2-(2-tert-butyl-5-nitro-phenoxy)-ethyl]-piperidine.

Sources & evidence

ORD record
ord-00375ee15b7f4b8b87c66ddaf41cccb2
Source dataset
uspto-grants-2014_02
Patent number
US08642624B2

Reaction notes

Loading…