反应详情

40 g of 4-chloro-6-ethyl-5-fluoropyrimidine was added to 400 ml of acetonitrile, and 28 ml of thiophenol was added thereto, followed by lowering the temperature to 10° C. 43.39 ml of diisopropylethylamine was added to the resulting solution, and reacted for 2 hours while maintaining the temperature at room temperature. 65 ml of dichloromethane and 200 ml of water were added to the resulting mixture to separate layer, and the resulting aqueous mixture was extracted with 200 ml of dichloromethane. The organic layer was dried over magnesium sulfate and concentrated under a reduced pressure to obtain the title compound as an oil (63.6 g, yield: 95%).

1. additionwas added
2. customto 10° C
3. customreacted for 2 hours
4. customto separate layer
5. extractionthe resulting aqueous mixture was extracted with 200 ml of dichloromethane
6. dry with materialThe organic layer was dried over magnesium sulfate
7. concentrationconcentrated under a reduced pressure