Methanol → HCID 86645230, compound

HRID 2384589Notes

Reaction equation

HRID 2384589 reaction equation
[Cl:1][C:2]1[C:18]([N+:19]([O-])=O)=[C:17]([F:22])[CH:16]=[CH:15][C:3]=1[C:4]([NH:6][S:7]([N:10]([CH:12]([CH3:14])[CH3:13])[CH3:11])(=[O:9])=[O:8])=[O:5].CO.[H][H]>C1(C)C=CC=CC=1.[Pt]>[Cl:1][C:2]1[C:18]([NH2:19])=[C:17]([F:22])[CH:16]=[CH:15][C:3]=1[C:4]([NH:6][S:7]([N:10]([CH:12]([CH3:14])[CH3:13])[CH3:11])(=[O:9])=[O:8])=[O:5]

Participants

6

Reactant 3

HCID 887MethanolHCID 68493096HCID 68493096, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 86645230HCID 86645230, compound

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 1140TolueneSolvent

Conditions

Temperature
70 °C

Procedure

8.00 g (23.0 mmol) of N-(2-chloro-4-fluoro-3-nitrobenzoyl)-N′-isopropyl-N′-methylsulfamide in 33 g of toluene and 8 g of methanol were admixed with 190 mg (0.055 mol %) of 3% Pt/C and hydrogenated with 5 bar of hydrogen with stirring at 70° C. After 12 h the solution was depressurized, the reaction mixture was filtered and the solvent was removed by distillation. This gave 4.7 g (64%) of the title compound in the form of a solid (m.p.: 147-149° C.).

Workup

  1. filtrationthe reaction mixture was filtered
  2. customthe solvent was removed by distillation

Sources & evidence

ORD record
ord-ee21aad8bf914493a6b379698eb1c338
Source dataset
uspto-grants-2012_09
Patent number
US08263806B2

Reaction notes

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