1-Methylpiperazine → HCID 67240387, compound

HRID 2384610Notes

Reaction equation

CS[C:3]1[S:4][C:5](=[CH:9][C:10]2[CH:11]=[C:12]3[C:16](=[CH:17][CH:18]=2)[N:15]([CH2:19][C:20]2[CH:27]=[CH:26][C:23]([C:24]#[N:25])=[CH:22][C:21]=2[C:28]([F:31])([F:30])[F:29])[N:14]=[CH:13]3)[C:6](=[O:8])[N:7]=1.[CH3:32][N:33]1[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]1>>[CH3:32][N:33]1[CH2:38][CH2:37][N:36]([C:3]2[S:4][C:5](=[CH:9][C:10]3[CH:11]=[C:12]4[C:16](=[CH:17][CH:18]=3)[N:15]([CH2:19][C:20]3[CH:27]=[CH:26][C:23]([C:24]#[N:25])=[CH:22][C:21]=3[C:28]([F:30])([F:31])[F:29])[N:14]=[CH:13]4)[C:6](=[O:8])[N:7]=2)[CH2:35][CH2:34]1

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 67240795HCID 67240795, compound

Product 1

HCID 67240387HCID 67240387, compound

Procedure

4-{5-[2-(4-Methyl-piperazin-1-yl)-4-oxo-4H-thiazol-5-ylidenemethyl]-indazol-1-ylmethyl}-3-trifluoromethyl-benzonitrile was prepared from 4-[5-(2-methylsulfanyl-4-oxo-4H-thiazol-5-ylidenemethyl)-indazol-1-ylmethyl]-3-trifluoromethyl-benzonitrile and 1-methyl-piperazine following General Procedure C.

Sources & evidence

ORD record: ord-3f55156857ae41c591eecc303c676292
Source dataset: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08263781B2

Reaction notes

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