HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2384615Generated: October 30, 2026
4-Fluoro-2-(trifluoromethyl)benzaldehyde → HCID 81647511, compound
https://huagongshe.com/reaction/2384615
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Fluoro-2-(trifluoromethyl)benzaldehyde | HCID 522940 | — |
| Reactant | Sodium methanethiolate | HCID 4378561 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 81647511 | HCID 81647511 | — |
Reaction Steps
To a DMF solution (5 mL) containing 935.3 mg (4.87 mmol) of 4-fluoro-2-(trifluoromethyl)benzaldehyde was added sodium thiomethoxide (414.2 mg, 5.84 mmol). The mixture was stirred at 90° C. for 2 h, partitioned between EtOAc and water. The EtOAc extracts were washed with brine, dried over Na2SO4 and evaporated to afford desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08263781B2 |
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| Source dataset | uspto-grants-2012_09 |
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| ORD ID | ord-59194f586fcd4260b65b19fdff8c6abb |
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| Source note | uspto-grants-2012_09 |
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