4-Fluoro-2-(trifluoromethyl)benzaldehyde → HCID 81647511, compound

HRID 2384615Notes

Reaction equation

HRID 2384615 reaction equation
F[C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([C:10]([F:13])([F:12])[F:11])[CH:3]=1.[CH3:14][S-:15].[Na+]>CN(C=O)C>[CH3:14][S:15][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([C:10]([F:13])([F:12])[F:11])[CH:3]=1

Participants

4

Reactant 2

HCID 5229404-Fluoro-2-(trifluoromethyl)benzaldehydeHCID 4378561Sodium methanethiolate

Product 1

HCID 81647511HCID 81647511, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
90 °C

Procedure

To a DMF solution (5 mL) containing 935.3 mg (4.87 mmol) of 4-fluoro-2-(trifluoromethyl)benzaldehyde was added sodium thiomethoxide (414.2 mg, 5.84 mmol). The mixture was stirred at 90° C. for 2 h, partitioned between EtOAc and water. The EtOAc extracts were washed with brine, dried over Na2SO4 and evaporated to afford desired product.

Workup

  1. custompartitioned between EtOAc and water
  2. washThe EtOAc extracts were washed with brine
  3. dry with materialdried over Na2SO4
  4. customevaporated

Sources & evidence

ORD record
ord-59194f586fcd4260b65b19fdff8c6abb
Source dataset
uspto-grants-2012_09
Patent number
US08263781B2

Reaction notes

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