反应详情

2-Methyl-2-(4-nitro-phenyl)-propionic acid methyl ester (2.1 g) was dissolved in THF (70 ml) and acetic acid (5 ml) and Zn (10 g) were added. The mixture was stirred for 1 h and filtered through Celite®. The filtrate was rinsed with EtOAc and the organics were evaporated to a residue which was purified on silica gel chromatography (40% EtOAc/hexanes) to provide the desired compound as a yellow oil. M+H 194.

1. filtrationfiltered through Celite®
2. washThe filtrate was rinsed with EtOAc
3. customthe organics were evaporated to a residue which
4. customwas purified on silica gel chromatography (40% EtOAc/hexanes)